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Determination of urinary indolic metabolites

✍ Scribed by Alvin J. Greenberg; Roger Ketcham

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
423 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis

A rapid mass spectral assay for tryptophol, 5-hydroxytryptophol, and 3-indoleacetic acid, employing stable-isotope labeled internal standards, is described. The compounds were extracted from urine or buffer with ethyl acetate and quantitatively measured by chemical-ionization mass spectrometry. The calibration curves were linear over a range of 0.06--2.8 microgram/ml. The technique was applied to the analysis of urine from patients with carcinoid tumors. In addition, the first synthesis of 5-methoxy-3-indoleacrylic acid is reported.

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