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Identification of urinary metabolites of flavanone in the rat

✍ Scribed by Helge Buset; Ronald R. Scheline

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
904 KB
Volume
6
Category
Article
ISSN
1076-5174

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✦ Synopsis

The urinary metabolites of flavanone in the rat were investigated using a gas chromatographic mass spectrometric method employing an OV-1 capillary column. Forty-three metabolites were detected and the most prominent of these were identified. The most common metabolic reactions were reduction of the keto group and hydroxylation at the 3or 6-positions. Little hydroxylation occurred in ring B. The major metabolites were flavan-4a-01, trans -3-hydroxyflavan-40 -ol,6-hydroxyflavanone and 6-hydroxyflavan-40 -01. Gas chromatographic analysis of underivatized flavanone metabolites, especially with stainless steel columns, results in the formation of dehydrated products including flavone, flav-3-ene and flavanone itself.

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