The urine collected from three dogs for 24 hr. after oral administration of but~olol-'~C contained 61.2% of the administered radioactivity. An acidic metabolite, representing 16% of the urinary IrC, was purified by ether extraction and preparative TLC. The methyl ester of the metabolite was prepared
l-bunolol metabolism in rats: Identification of urinary metabolites
β Scribed by Franz-Josef Leinweber; Joseph M. Szpiech; Frederick J. di Carlo
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 305 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
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The urinary metabolites of p-phenoxyphenol methanesulfonate ( I ) in rat and man were characterired. The drug was extensively nietabolired in both cpecies and excreted mainly in the form of conjugated phenolic compounds. The major metabolite of I in both species was identified as the conjugated mono
## Abstract After the intraperitoneal administration of high doses of ^14^Cβ and ^3^Hβlabelled retinoic acid (**1**) to rats three major urinary metabolites have been isolated in microgram amounts by use of column, thinβlayer and highβpressure liquid chromatography. Their structures were elucidated