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Synthesis of Urinary Metabolites of Retinoic Acid

✍ Scribed by Tong Hei Kim; Kenji Kon; Sachihiko Isoe

Publisher
John Wiley and Sons
Year
1983
Tongue
German
Weight
140 KB
Volume
66
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Urinary metabolites 5‐methyl‐5‐[2‐(2,6,6‐trimethyl ‐3‐oxo‐1‐cyclohexen‐1‐yl)‐vinyl]‐2‐tetrahydrofuranone (1) and 5‐[2‐(6‐hydroxymethyl‐2, 6‐dimethyl‐3‐oxo‐1‐ cyclohexen‐1‐yl)vinyl]‐5‐methyl‐2‐tetrahydrofuranone (2) of retinoic acid have been synthesized from 4‐[2,2,6‐trimethyl‐3‐(tetrahydro‐2 H ‐pyran‐2‐yl)oxy‐1‐cyclohexen‐1‐yl]‐3‐buten‐2‐one (4) and methyl 2‐(3,3‐ethylenedioxy‐1‐butenyl)‐1, 3‐dimethyl‐4‐oxo‐2‐cyclohexene‐1‐carboxylate (5).

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