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Determination of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human hair by solid-phase extraction and gas chromatography-mass spectrometry

✍ Scribed by S. Hegstad; E. Lundanes; R. Reistad; L. S. Haug; G. Becher; J. Alexander

Book ID
110550181
Publisher
Springer
Year
2000
Tongue
English
Weight
541 KB
Volume
52
Category
Article
ISSN
0009-5893

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## 2-Amino -1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic aromatic amine found in cooked meat. It is metabolically activated by the human cytochrome P450 enzymes to form the carcinogenic metabolite N 2 -OH-PhIP. PhIP has been found to induce tumors in rats and is

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The base pair substitution mutational profiles in-position (CCCrCTC; 96-99% of total). Base substiduced by the heterocyclic amine cooked food muta-tution mutagenesis induced by heterocyclic amines gens PhIP and IQ in Salmonella typhimurium strains related to PhIP is generally SOS-dependent, requir-T