Formation of the food associated carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in model systems
✍ Scribed by Michael Murkovic; Hans-Jörg Weber; Sandra Geiszler; Karin Fröhlich; Werner Pfannhauser
- Book ID
- 108434083
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 188 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0308-8146
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📜 SIMILAR VOLUMES
Mutations induced by substances formed during food cooking are a field of growing interest; for a better comprehension of the mechanism of action of these carcinogens, simple routes to their synthesis are needed. In this letter we describe an easy method for 2-amino-l-methyl-6-phenylimidazo[4,5-b]py
## Abstract 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIP‐DNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed
Indole-3-carbinol (I3C), a naturally occurring inhibitor of experimental carcinogenesis, was evaluated for its possible inhibitory effect on DNA-adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary mutagen, in female F344 rats. PhIP is a mammary carcinogen in female