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Determination of the enantiomers of metoprolol and its major acidic metabolite in human urine by high-performance liquid chromatography with fluorescence detection

✍ Scribed by Feng Li; Sam F. Cooper; Michel Côté

Publisher
Elsevier Science
Year
1995
Weight
511 KB
Volume
668
Category
Article
ISSN
0378-4347

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Determination of metoprolol in human pla
Determination of metoprolol in human plasma and urine by high-performance liquid chromatography with fluorescence detection
✍ Bilal Yilmaz; Ali Asci; Sakir Arslan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5 μm, 250 mm×4.6 mm id) using fluorescence detection with λ~ex~=2