A method based o n paper chromatography and biological assay has been developed for the determination of p-hydroxyphenoxy methyl penicillin in phenoxy methyl penicillin (penicillin V) fermentation samples. The penicillin broth is extracted into methyl isobutyl ketone. The extract is chromatographed
Determination of p-hydroxyphenoxyacetic acid in phenoxymethyl penicillin fermentations
β Scribed by Jan Birner
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 388 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
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These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.