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Determination of metoprolol and its two metabolites in human plasma and urine by high performance liquid chromatography with fluorescence detection and its application in pharmacokinetics

✍ Scribed by Xu, Tao; Bao, Shihui; Geng, Peiwu; Luo, Jun; Yu, Lei; Pan, Peipei; Chen, Yi; Hu, Guoxin

Book ID
121468942
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
898 KB
Volume
937
Category
Article
ISSN
1873-376X

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Determination of metoprolol in human pla
Determination of metoprolol in human plasma and urine by high-performance liquid chromatography with fluorescence detection
✍ Bilal Yilmaz; Ali Asci; Sakir Arslan πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 143 KB πŸ‘ 2 views

## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5 μm, 250 mmΓ—4.6 mm id) using fluorescence detection with Ξ»~ex~=2