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Determination of Dissociation Constants for Protein−Ligand Complexes by Electrospray Ionization Mass Spectrometry

✍ Scribed by Tjernberg, Agneta; Carnö, Sofi; Oliv, Frida; Benkestock, Kurt; Edlund, Per-Olof; Griffiths, William J.; Hallén, Dan

Book ID
126556196
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
87 KB
Volume
76
Category
Article
ISSN
0003-2700

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## Abstract We describe an approach for the determination of binding constants for protein–ligand complexes with electrospray ionization mass spectrometry, based on the observation of unbound ligands competing for binding to a protein target. For the first time, dissociation constants lower than pi