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Improved Accuracy of Low Affinity Protein–Ligand Equilibrium Dissociation Constants Directly Determined by Electrospray Ionization Mass Spectrometry

✍ Scribed by Lucie Jaquillard; Fabienne Saab; Françoise Schoentgen; Martine Cadene

Book ID
113110696
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
664 KB
Volume
23
Category
Article
ISSN
1044-0305

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## Abstract We describe an approach for the determination of binding constants for protein–ligand complexes with electrospray ionization mass spectrometry, based on the observation of unbound ligands competing for binding to a protein target. For the first time, dissociation constants lower than pi