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Determination of Absolute Stereochemistry of 2-Alkylmorpholines by a 13C NMR Study of Steroid Derivatives

✍ Scribed by L. Fielding; N. Hamilton; R. McGuire; M. Maidment; A. C. Campbell

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
340 KB
Volume
34
Category
Article
ISSN
0749-1581

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✦ Synopsis

Information about the absolute stereochemistry (configuration) of some diastereomeric pairs of 28-(2alkylmorpholinyl)-3a-hydroxy-5a-pregnanes is available from the 13C chemical shifts of the C-3' and C-5' morpholine carbons. A series of anaesthetic compounds can be allocated to one group of R configuration at the 2-alkylmorpholine with C-3' and C-5' at around 51 and 52 ppm, and another group of S configuration with C-3' and C-5' at around 45 and 57 ppm.

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