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Determination by 1D NOE studies of the stereochemistry of a tricyclic 2-hydroxytetrahydrofuran derivative obtained by hydroformylation of (1R )-(-)-myrtenol

✍ Scribed by S. Sirol; J.-P. Gorrichon; P. Kalck; P. M. Nieto; G. Commenges


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
136 KB
Volume
37
Category
Article
ISSN
0749-1581

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✦ Synopsis


The structure of a new, optically pure 2-hydroxytetrahydrofuran tricyclic compound resulting from the hydroformylation of (1R)-([)-myrtenol was resolved by one-and two-dimensional 1H and 13C NMR. The conÐgurations of the three new asymmetric centres are discussed on the basis of J(H,H) coupling constants, NOE measurements and molecular modelling.