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Detection of apoptosis in acute promyelocytic leukemia cells in vivo during differentiation-induction with all-trans retinoic acid in combination with chemotherapy

✍ Scribed by Atsushi Sato; Masue Imaizumi; Toshiaki Saito; Miyako Yoshinari; Hoshiro Suzuki; Yutaka Hayashi; Kazuie Iinuma

Book ID
114119650
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
320 KB
Volume
23
Category
Article
ISSN
0145-2126

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## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A