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Detection and sequence of mutations in the factor VIII gene of haemophiliacs

โœ Scribed by Gitschier, Jane; Wood, William I.; Tuddenham, Edward G. D.; Shuman, Marc A.; Goralka, Therese M.; Chen, Ellson Y.; Lawn, Richard M.


Book ID
109739194
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
921 KB
Volume
315
Category
Article
ISSN
0028-0836

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Hemophilia A is a common X-linked bleeding disorder caused by mutations in the coagulation factor VIII gene. The entire coding and essential sequences of the factor VIII gene were generated by a combination of genomic DNA amplification and long reverse transcription-polymerase chain reaction (long R