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Nonsense mutation in factor VIII gene of a severe haemophiliac patient with anti-factor VIII antibody

✍ Scribed by Sadaaki Mikai; Takuya Nishimura; Hiroyuki Naka; Kuninori Kuze; Hiromu Fukui; Masahide Tone; Tamotsu Hashimoto-Gotoh


Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
469 KB
Volume
33
Category
Article
ISSN
1435-232X

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Hemophilia A is a common X-linked bleeding disorder caused by mutations in the coagulation factor VIII gene. The entire coding and essential sequences of the factor VIII gene were generated by a combination of genomic DNA amplification and long reverse transcription-polymerase chain reaction (long R