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A deletion involving intron 13 and exon 14 of factor VIII gene in a haemophiliac with anti-factor VIII antibody

โœ Scribed by Sadaaki Mikami; Takuya Nishimura; Hiroyuki Naka; Kuninori Kuze; Hiromu Fukui


Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
484 KB
Volume
33
Category
Article
ISSN
1435-232X

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In an attempt to characterize disease producing mutations in the factor VIII gene we screened exons 4, 7, 8, 11, 12 and 16 by PCR-SSCP (polymerase chain reactionsingle strand conformation polymorphism), in 12 randomly selected haemophilia A patients. These exons were chosen because they have been re