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Characterization of a partial deletion of the factor VIII gene in a haemophiliac with inhibitor

✍ Scribed by B. Bardoni; M. Sampietro; M. Romano; M. Crapanzano; P. M. Mannucci; G. Camerino


Publisher
Springer
Year
1988
Tongue
English
Weight
547 KB
Volume
79
Category
Article
ISSN
0340-6717

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In an attempt to characterize disease producing mutations in the factor VIII gene we screened exons 4, 7, 8, 11, 12 and 16 by PCR-SSCP (polymerase chain reactionsingle strand conformation polymorphism), in 12 randomly selected haemophilia A patients. These exons were chosen because they have been re