Hemophilia A is a common X-linked bleeding disorder caused by mutations in the coagulation factor VIII gene. The entire coding and essential sequences of the factor VIII gene were generated by a combination of genomic DNA amplification and long reverse transcription-polymerase chain reaction (long R
β¦ LIBER β¦
Restriction endonuclease mapping of six novel deletions of the factor VIII gene in hemophilia A
β Scribed by Hagop Youssoufian; Carol K. Kasper; Deborah G. Phillips; Haig H. Kazazian; Stylianos E. Antonarakis
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 572 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0340-6717
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Hemophilia A is a common X-linked bleeding disorder caused by various types of mutations in the factor VIII gene F8C. The most common intron 22-inversion is responsible for about 40% of the severe hemophilia A cases while large deletions, point mutations and small (less than 100 bp) deletions or ins