𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Designing peptide and protein ligands for biological receptors

✍ Scribed by Victor J. Hruby; Shubh D. Sharma

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
1004 KB
Volume
2
Category
Article
ISSN
0958-1669

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✦ Synopsis

A clearer understanding of structure-function relationships of protein hormone-receptor systems is emerging from the increased use of molecular biology approaches. On the other hand, the introduction of rationally designed conformation constraints into peptide hormones and neurotransmitters is leading to the development of highly receptor-selective ligands that allow further investigations into the topographic modulation of their bioactivities and rational design principles for peptide antagonists.

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## Abstract Patented signal analytic algorithms applied to hydrophobically transformed, numerical amino acid sequences have previously been used to design short, protein‐targeted, L or D retro‐inverso peptides. These peptides have demonstrated allosteric and/or indirect agonist effects on a variety