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Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors †

✍ Scribed by Francotte, Pierre; de Tullio, Pascal; Goffin, Eric; Dintilhac, Gaëlle; Graindorge, Emmanuel; Fraikin, Pierre; Lestage, Pierre; Danober, Laurence; Thomas, Jean-Yves; Caignard, Daniel-Henri; Pirotte, Bernard


Book ID
126231189
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
94 KB
Volume
50
Category
Article
ISSN
0022-2623

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## Abstract A new method for the preparation of 4‐substituted 3,4‐dihydro‐1__H__‐2,1,3‐benzothiadiazine 2,2‐dioxides is described. Treatment of __t__‐butyl __N__‐phenylsulfamoylcarbamate derivatives (**1**) with different aldehydes afforded the corresponding intramolecular cyclized products **2** u