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Design, Synthesis, and Pharmacological Evaluation of Glutamate Carboxypeptidase II (GCPII) Inhibitors Based on Thioalkylbenzoic Acid Scaffolds

โœ Scribed by Stoermer, Doris; Vitharana, Dilrukshi; Hin, Niyada; Delahanty, Greg; Duvall, Bridget; Ferraris, Dana V.; Grella, Brian S.; Hoover, Randall; Rojas, Camilo; Shanholtz, Megan K.; Smith, Kyle P.; Stathis, Marigo; Wu, Ying; Wozniak, Krystyna M.; Slusher, Barbara S.; Tsukamoto, Takashi

Book ID
120228837
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
704 KB
Volume
55
Category
Article
ISSN
0022-2623

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A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.