✦ LIBER ✦

Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

✍ Scribed by Lynn S. Gossett; Lillian L. Habeck; Susan B. Gates; Sherri L. Andis; John F. Worzalla; Richard M. Schultz; Laurane G. Mendelsonn; William Kohler; Manohar Ratnam; Gerald B. Grindey; Chuan Shih

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 170 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00053-4

No coin nor oath required. For personal study only.

✦ Synopsis

A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.

📜 SIMILAR VOLUMES

ChemInform Abstract: Protein Structure-B

ChemInform Abstract: Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition.

✍ M. D. VARNEY; C. L. PALMER; W. H. III ROMINES; T. BORITZKI; S. A. MARGOSIAK; R. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition. -A novel series of inhibitors such as (I) and (II) are prepared and designed using the X