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Synthesis and Biological Evaluation of Hydroxamate-Based Inhibitors [cf. (IX)] of Glutamate Carboxypeptidase II.

✍ Scribed by Doris Stoermer; Qun Liu; Monicia R. Hall; Juliet M. Flanary; Ajit G. Thomas; Camilo Rojas; Barbara S. Slusher; Takashi Tsukamoto

Book ID
101947854
Publisher
John Wiley and Sons
Year
2003
Weight
131 KB
Volume
34
Category
Article
ISSN
0931-7597

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A series of N-substituted 3-(2-mercaptoethyl)-1H-indole-2-carboxylic acids were synthesized as inhibitors of glutamate carboxypeptidase II (GCPII). Those containing carboxybenzyl or carboxyphenyl groups at the N-position exhibited potent inhibitory activity against GCPII. These indole-based compound