A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.
โฆ LIBER โฆ
ChemInform Abstract: Synthesis and Biological Evaluation of a New Series of Dihydrofolate Reductase Inhibitors Based on the 4-(2,6-Diamino-5-pyrimidinyl)alkyl-L- glutamic Acid Structure.
โ Scribed by L. S. GOSSETT; L. L. HABECK; S. B. GATES; S. L. ANDIS; J. F. WORZALLA; R. M. SCHULTZ; L. G. MENDELSOHN; W. KOHLER; M. RATNAM; G. B. GRINDEY; C. SHIH
- Book ID
- 112033395
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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