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ChemInform Abstract: Synthesis and Biological Evaluation of N-(4-(2-trans-(((2,6-Diamino-4( 3H)-oxopyrimidin-5-yl)methyl)thio)cyclobutyl)benzoyl)-L-glutamic Acid ( I), a Novel 5-Thiapyrimidinone Inhibitor of Dihydrofolate Reductase.

โœ Scribed by M. D. VARNEY; W. H. III ROMINES; T. BORITZKI; S. A. MARGOSIAK; C. BARTLETT; E. J. HOWLAND


Book ID
112029672
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis and biological evaluation of a
โœ Lynn S. Gossett; Lillian L. Habeck; Susan B. Gates; Sherri L. Andis; John F. Wor ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 170 KB

A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.