A four step degradation of the C8 ethyl ketone of apicidin provided a route to the C6 aldehyde intermediate and several mechanism-based transition state inhibitors of histone deacetylase. The compounds generated herein delineate the significance of apicidin's side chain, highlighted by the high affi
Design, Synthesis, and Evaluation of the Transition- State Inhibitors of Coelenterazine Bioluminescence: Probing the Chiral Environment of Active Site
β Scribed by Nakamura, Hideshi; Wu, Chun; Inouye, Satoshi; Murai, Akio
- Book ID
- 120634958
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 50 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0002-7863
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The design as well as the synthesis, resolution, and biological evaluation of the neutral endopeptidase 24.11 inhibitors, (1S,2R,5S)-(-)-[(2-mercapto-5-phenyl-cyclopentanecarbonyl)amino]-acetic acid and (1R,2S,5R)-(+)- [(2-mercapto-5-phenyl-cyclopentanecarbonyl)-amino]-acetic acid are described.