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Probing the Active Site of Candida glabrata Dihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

โœ Scribed by Jieying Liu; David B. Bolstad; Adrienne E. Smith; Nigel D. Priestley; Dennis L. Wright; Amy C. Anderson


Book ID
111368624
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
703 KB
Volume
73
Category
Article
ISSN
1747-0277

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High resolution crystal structures of tr
โœ Rajaram Venkatesan; Markus Alahuhta; Petri M. Pihko; Rik K. Wierenga ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Cold Spring Harbor Laboratory Press ๐ŸŒ English โš– 720 KB

## Abstract The key residue of the active site of triosephosphate isomerase (TIM) is the catalytic glutamate, which is proposed to be important (i) as a catalytic base, for initiating the reaction, as well as (ii) for the subsequent proton shuttling steps. The structural properties of this glutamat