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Design, Synthesis, and Evaluation of a Pyrrolinone-Based Matrix Metalloprotease Inhibitor

โœ Scribed by Smith, Amos B.; Nittoli, Thomas; Sprengeler, Paul A.; Duan, James J.-W.; Liu, Rui-Qin; Hirschmann, Ralph F.


Book ID
126396569
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
82 KB
Volume
2
Category
Article
ISSN
1523-7060

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A series of succinate-derived macrocyclic amides 1 were synthezized using ring-closing metathesis in the key step. The substrate scope includes rings of 11 to 14 members. The cyclic dicarboxylic acids 1 represent a family of new model compounds for potential zinc metalloprotease inhibitors. The meta