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Design, Synthesis, and Binding Affinities of Pyrrolinone-Based Somatostatin Mimetics

โœ Scribed by Smith, Amos B.; Charnley, Adam K.; Mesaros, Eugen F.; Kikuchi, Osamu; Wang, Wenyong; Benowitz, Andrew; Chu, Chi-Lien; Feng, Jin-Jye; Chen, Kuo-Hsin; Lin, Atsui; Cheng, Fong-Chi; Taylor, Laurie; Hirschmann, Ralph


Book ID
118129937
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
121 KB
Volume
7
Category
Article
ISSN
1523-7060

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Synthesis of Somatostatin Mimetics Based
โœ Vincent Chagnault; Jรฉrรดme Lalot; Paulโ€…V. Murphy ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 355 KB

## Abstract The synthesis of novel somatostatin mimetics from 1โ€deoxynojirimycin (DNJ) is described. The dipeptide mimetic, which respectively displayed the side chains of tryptophan and lysine at the nitrogen and O6 atoms of the iminosugar scaffold is a ligand (__K~i~__=3.2โ€…ฮผM) for the human somat