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Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin®

✍ Scribed by Dominique Damour; Michel Barreau; Jean-Charles Blanchard; Marie-Claude Burgevin; Adam Doble; Frederic Herman; Guy Pantel; Evelyne James-Surcouf; Marc Vuilhorgne; Serge Mignani; Lydie Poitout; Yves Le Merrer; Jean-Claude Depezay


Book ID
103983461
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
317 KB
Volume
6
Category
Article
ISSN
0960-894X

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Design and synthesis of functionalized t
✍ Kaori Sakurai; Daniel Kahne 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 630 KB

Oligosaccharides represent potentially useful scaffolds for the development of peptidomimetics. We report here the design and synthesis of functionalized trisaccharides modeled after an α-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2. The trisaccharide scaffold was