Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin®
✍ Scribed by Dominique Damour; Michel Barreau; Jean-Charles Blanchard; Marie-Claude Burgevin; Adam Doble; Frederic Herman; Guy Pantel; Evelyne James-Surcouf; Marc Vuilhorgne; Serge Mignani; Lydie Poitout; Yves Le Merrer; Jean-Claude Depezay
- Book ID
- 103983461
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 317 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Oligosaccharides represent potentially useful scaffolds for the development of peptidomimetics. We report here the design and synthesis of functionalized trisaccharides modeled after an α-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2. The trisaccharide scaffold was