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Design and synthesis of functionalized trisaccharides as p53-peptide mimics

✍ Scribed by Kaori Sakurai; Daniel Kahne

Book ID
104097813
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
630 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

Oligosaccharides represent potentially useful scaffolds for the development of peptidomimetics. We report here the design and synthesis of functionalized trisaccharides modeled after an Ξ±-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2. The trisaccharide scaffold was obtained efficiently by applying the sulfoxide glycosylation reaction as a key methodology.

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