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Design and Synthesis of Sialyl Lewisx Mimics as E- and P-Selectin Inhibitors

✍ Scribed by Neelu Kaila; Bert E. Thomas IV

Publisher
John Wiley and Sons
Year
2003
Weight
74 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract The selectins are a family of cell‐adhesion proteins that mediate the rolling of leukocytes on activated endothelial cells through the recognition of the carbohydrate epitope sialyl Lewis^x^ (sLe^x^). Control of the leukocyte‐endothelial cell adhesion process may prove useful in cases w

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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Phosphorylation of surface E-selectin and the effect of soluble ligand (Sialyl Lewis") on the half-life of E-selectin\* E-selectin (ELAM-1) is an adhesion molecule for leukocytes that is transiently expressed on endothelial cells. Following cell surface expression of E-selectin on human umbilical ve