Design, synthesis, and biological activity of a peptide mimic of vasopressin
β Scribed by Bryan, William M.; Hempel, Judith C.; Huffman, William F.; Marshall, Garland R.; Moore, Michael L.; Silvestri, Joanne; Stassen, Frans L.; Stefankiewicz, James S.; Sulat, Lynn; Webb, R. Lee
- Book ID
- 126075687
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 460 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2623
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The synthesis and preliminary biological evaluation of a nonpeptide mimic of the immunosuppressant tripeptide (Lys-Pro-Arg) is described.
## Abstract Four novel octreotide analogs with cellβpenetrating peptides (CPPs) at the __N__βterminus or __C__βterminus were synthesized by a stepwise Fmoc solidβphase synthesis strategy. The synthesized peptides were analyzed and characterized using reverse phase HPLC and MALDIβTOF mass spectromet