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โœฆ   LIBER   โœฆ

Design and Synthesis of Potential Macrocyclic Zinc Metalloprotease Inhibitors

โœ Scribed by Bao-Xiang Zhao; Marco Schaudt; Siegfried Blechert

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
82 KB
Volume
24
Category
Article
ISSN
0256-7660

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โœฆ Synopsis

A series of succinate-derived macrocyclic amides 1 were synthezized using ring-closing metathesis in the key step. The substrate scope includes rings of 11 to 14 members. The cyclic dicarboxylic acids 1 represent a family of new model compounds for potential zinc metalloprotease inhibitors. The metathesis precursors were provided by amide coupling of tert-butyl 3-carboxyhex-5-enoate 2 with numerous side chain alkenylated amino acid esters of general type 3 derived from L-tyrosine and L-cysteine.

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The design and synthesis of inhibitors of dethiobiotin synthetase as potential herbicides
โœ Rendina, Alan R; Taylor, Wendy S; Gibson, Katharine; Lorimer, George; Rayner, De ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 246 KB ๐Ÿ‘ 1 views

Dethiobiotin synthetase (DTBS ; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in-vitro activities of these potential inhibitors v