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Design and Synthesis of Matrix Metalloprotease Photoaffinity Trimodular Probes

โœ Scribed by Wenwei QIU; Jie XU; Xin LI; Li ZHONG; Jingya LI; Jia LI; Fajun NAN

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
184 KB
Volume
27
Category
Article
ISSN
0256-7660

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โœ Bao-Xiang Zhao; Marco Schaudt; Siegfried Blechert ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 82 KB ๐Ÿ‘ 1 views

A series of succinate-derived macrocyclic amides 1 were synthezized using ring-closing metathesis in the key step. The substrate scope includes rings of 11 to 14 members. The cyclic dicarboxylic acids 1 represent a family of new model compounds for potential zinc metalloprotease inhibitors. The meta