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Design, Synthesis, and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A

✍ Scribed by Ikejiri, Masahiro; Bernardo, M. Margarida; Meroueh, Samy O.; Brown, Stephen; Chang, Mayland; Fridman, Rafael; Mobashery, Shahriar

Book ID: 126427896
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 170 KB
Volume: 70
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo050339+

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Design, Synthesis, and Evaluation of the First Mechanism-Based Inhibitor of Glucosamine 6-Phosphate Synthase. -The first example of the title inhibitor, the compound (I), a glutamine derivative bearing a latent electrophilic function, is prepared starting from suitably protected glutamine. (I) is st