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Design, Synthesis, and Biological Evaluation of New Inhibitors of the Endocannabinoid Uptake: Comparison with Effects on Fatty Acid Amidohydrolase

✍ Scribed by López-Rodríguez, María L.; Viso, Alma; Ortega-Gutiérrez, Silvia; Fowler, Christopher J.; Tiger, Gunnar; de Lago, Eva; Fernández-Ruiz, Javier; Ramos, José A.


Book ID
120821721
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
158 KB
Volume
46
Category
Article
ISSN
0022-2623

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✍ Lynn S. Gossett; Lillian L. Habeck; Susan B. Gates; Sherri L. Andis; John F. Wor 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 170 KB

A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.