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Design, Synthesis, and Biological Evaluation of the N-Diarylalkenyl-piperidinecarboxylic Acid Derivatives as GABA Uptake Inhibitors (I).

✍ Scribed by Jianbin Zheng; Ren Wen; Xiaomin Luo; Guoqiang Lin; Jiange Zhang; Linfeng Xu; Lihe Guo; Hualiang Jiang


Publisher
John Wiley and Sons
Year
2006
Weight
22 KB
Volume
37
Category
Article
ISSN
0931-7597

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Dedicated to Professor Dieter Seebach on the occasion of his 65th birthday Two orthogonally protected SAA building blocks were used in the synthesis of eight novel analogues of the CaaX motif present in the natural substrates of protein:geranylgeranyltransferase I (PGGT I), an enzyme involved in the