Design, development and evaluation of novel dual PPARδ/PPARγ agonists
✍ Scribed by Gathiaka, Symon; Nanayakkara, Gayani; Boncher, Tracey; Acevedo, Orlando; Wyble, Johnathon; Patel, Sagar; Patel, Akash; Shane, Mary Elizabeth; Bonkowski, Blake; Wieczorek, Jason; Rong, Yinghui; Huggins, Kevin; Smith, Forest; Amin, Rajesh H.
- Book ID
- 120163531
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 1022 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0960-894X
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract **The inside cover picture shows** the X‐ray‐determined binding of an α‐ethoxy‐phenyl‐propionic acid‐derived dual PPARα/γ agonist in complex with PPARα (yellow) and PPARγ (blue). The high α‐selectivity of this phenylthiazole (IC~50~ γ/α = 37; EC~50~ γ/α = 7) can be rationalized mainly b