✦ LIBER ✦

ChemInform Abstract: Design and Synthesis of Novel and Potent Amide Linked PPARγ/δ Dual Agonists.

✍ Scribed by Qing Shi; et al. et al.

Publisher: John Wiley and Sons
Year: 2008
Weight: 20 KB
Volume: 39
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200811114

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Design, Synthesis,

ChemInform Abstract: Design, Synthesis, and Evaluation of Novel Aryl-Tetrahydropyridine PPARα/γ Dual Agonists.

✍ Chun Ho Lee; et al. et al. 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 20 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Design and Biological Evaluation of Nove

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

✍ Uwe Grether; Agnes Bénardeau; Jörg Benz; Alfred Binggeli; Denise Blum; Hans Hilp 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 357 KB

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of Novel Bis-oximinoalkanoic Acids as Potent PPARα Agonists.

✍ Harikishore Pingali; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 22 KB

## Abstract The oxazole ring in a recently reported selective PPARα agonist is replaced by different oxamino groups.

ChemInform Abstract: Identification of a

ChemInform Abstract: Identification of a Series of PPARγ/δ Dual Agonists via Solid-Phase Parallel Synthesis.

✍ Kevin G. Liu; Millard H. Lambert; Lisa M. Leesnitzer; William Oliver Jr.; Ronda 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Design and Synthesis of Novel PPARα/γ/δ

Design and Synthesis of Novel PPARα/γ/δ Triple Activators (IX) Using a Known PPARα/γ Dual Activator as Structural Template.

✍ John P. Mogensen; et al. et al. 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 161 KB

Inside Cover: Design and Biological Eval

Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009)

✍ Uwe Grether; Agnes Bénardeau; Jörg Benz; Alfred Binggeli; Denise Blum; Hans Hilp 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 439 KB

## Abstract **The inside cover picture shows** the X‐ray‐determined binding of an α‐ethoxy‐phenyl‐propionic acid‐derived dual PPARα/γ agonist in complex with PPARα (yellow) and PPARγ (blue). The high α‐selectivity of this phenylthiazole (IC~50~ γ/α = 37; EC~50~ γ/α = 7) can be rationalized mainly b