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Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

✍ Scribed by Uwe Grether; Agnes Bénardeau; Jörg Benz; Alfred Binggeli; Denise Blum; Hans Hilpert; Bernd Kuhn; Hans Peter Märki; Markus Meyer; Peter Mohr; Kurt Püntener; Susanne Raab; Armin Ruf; Daniel Schlatter

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
357 KB
Volume
4
Category
Article
ISSN
1860-7179

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Inside Cover: Design and Biological Eval
Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009)
✍ Uwe Grether; Agnes Bénardeau; Jörg Benz; Alfred Binggeli; Denise Blum; Hans Hilp 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 439 KB

## Abstract **The inside cover picture shows** the X‐ray‐determined binding of an α‐ethoxy‐phenyl‐propionic acid‐derived dual PPARα/γ agonist in complex with PPARα (yellow) and PPARγ (blue). The high α‐selectivity of this phenylthiazole (IC~50~ γ/α = 37; EC~50~ γ/α = 7) can be rationalized mainly b

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