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ChemInform Abstract: Design, Synthesis, and Evaluation of Novel Aryl-Tetrahydropyridine PPARα/γ Dual Agonists.

✍ Scribed by Chun Ho Lee; et al. et al.

Publisher
John Wiley and Sons
Year
2009
Weight
20 KB
Volume
40
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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## Abstract **The inside cover picture shows** the X‐ray‐determined binding of an α‐ethoxy‐phenyl‐propionic acid‐derived dual PPARα/γ agonist in complex with PPARα (yellow) and PPARγ (blue). The high α‐selectivity of this phenylthiazole (IC~50~ γ/α = 37; EC~50~ γ/α = 7) can be rationalized mainly b