✦ LIBER ✦

Design and Synthesis of trans -3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1 H -3-benzazepine (SB-414796): A Potent and Selective Dopamine D 3 Receptor Antagonist

✍ Scribed by Macdonald, Gregor J.; Branch, Clive L.; Hadley, Michael S.; Johnson, Christopher N.; Nash, David J.; Smith, Alexander B.; Stemp, Geoffrey; Thewlis, Kevin M.; Vong, Antonio K. K.; Austin, Nigel E.; Jeffrey, Phillip; Winborn, Kim Y.; Boyfield, Izzy; Hagan, Jim J.; Middlemiss, Derek N.; Reavill, Charlie; Riley, Graham J.; Watson, Jeannette M.; Wood, Martyn; Parker, Steve G.; Ashby, Charles R.

Book ID: 126450806
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 211 KB
Volume: 46
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm030817d

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Functionalized 2,5-Disubstituted Benzaze

Functionalized 2,5-Disubstituted Benzazepines: Stereoselective Synthesis of 3-Methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-2-carbonitrile and Related Derivatives.

✍ Jeff E. Cobb; Suganthini S. Nanthakumar; Randy Rutkowske; David E. Uehling 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl

(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship

✍ Baindur, Nandkishore; Tran, Mai; Niznik, Hyman B.; Guan, H. C.; Seeman, Phillip; 📂 Article 📅 1992 🏛 American Chemical Society 🌐 English ⚖ 887 KB

Radiosynthesis of a selective dopamine D

Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ([11C]SCH 23390)

✍ Hayden T. Ravert; Alan A. Wilson; Robert F. Dannals; Dean F. Wong; Henry N. Wagn 📂 Article 📅 1987 🏛 Elsevier Science ⚖ 200 KB

Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was compl

Synthesis and crystal structures of 7-br

Synthesis and crystal structures of 7-bromo-5-(2′-chloro)phenyl-3-hydroxy-1-methyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one and 7-bromo-5-(2′-chloro)phenyl-1-hexyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepin-2,3-dione

✍ Victor Ch. Kravtsov; Marina S. Fonari; Мaria Gdaniec; Victor I. Pavlovsky; Serge 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 724 KB

ChemInform Abstract: Novel 2,3,4,5-Tetra

ChemInform Abstract: Novel 2,3,4,5-Tetrahydro-1H-3-benzazepines with High Affinity and Selectivity for the Dopamine D3 Receptor.

✍ Christopher N. Johnson; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

ChemInform Abstract: A Simple Synthesis

ChemInform Abstract: A Simple Synthesis of 4a,5,6,8a-Tetrahydro-3-phenyl-4H,5H-pyrano(3,2-e) (1,2)oxazines, 4a,5,6,7a-Tetrahydro-3-phenyl-4H-furo(3,2-e) (1,2) oxazines and 6-Alkyl-3-phenyl-1,5,2-dioxazines.

✍ B. VENUGOPALAN; K. M. SATHE; E. PINTO DE SOUZA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB