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Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ([11C]SCH 23390)

✍ Scribed by Hayden T. Ravert; Alan A. Wilson; Robert F. Dannals; Dean F. Wong; Henry N. Wagner Jr

Publisher: Elsevier Science
Year: 1987
Weight: 200 KB
Volume: 38
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(87)90045-1

No coin nor oath required. For personal study only.

✦ Synopsis

Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [11C]iodomethane) and an average specific activity of approximately 1950 microCi/mumol calculated at the end of synthesis.

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