(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship

Radiosynthesis of a selective dopamine D

Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ([11C]SCH 23390)

✍ Hayden T. Ravert; Alan A. Wilson; Robert F. Dannals; Dean F. Wong; Henry N. Wagn 📂 Article 📅 1987 🏛 Elsevier Science ⚖ 200 KB

Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was compl

Synthesis and resolution of (.+-.)-7-chl

Synthesis and resolution of (.+-.)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor

✍ Chumpradit, Sumalee; Kung, Mei Pung; Billings, Jeffrey J.; Kung, Hank F. 📂 Article 📅 1991 🏛 American Chemical Society 🌐 English ⚖ 948 KB

ChemInform Abstract: Novel 2,3,4,5-Tetra

ChemInform Abstract: Novel 2,3,4,5-Tetrahydro-1H-3-benzazepines with High Affinity and Selectivity for the Dopamine D3 Receptor.

✍ Christopher N. Johnson; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Design and Synthesis of trans -3-(2-(4-(

Design and Synthesis of trans -3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1 H -3-benzazepine (SB-414796): A Potent and Selective Dopamine D 3 Receptor Antagonist

✍ Macdonald, Gregor J.; Branch, Clive L.; Hadley, Michael S.; Johnson, Christopher 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 211 KB

Stereoisomeric probes for the D1 dopamin

Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analog

✍ Neumeyer, John L.; Kula, Nora S.; Baldessarini, Ross J.; Baindur, Nandkishore 📂 Article 📅 1992 🏛 American Chemical Society 🌐 English ⚖ 759 KB

Synthesis and resolution of (.+-.)-7-chl

Synthesis and resolution of (.+-.)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor [Erratum to document cited in CA114(13):122017d]

✍ Chumpradit, Sumalee; Kung, Mei Pung; Billings, Jeffrey J.; Kung, Hank F. 📂 Article 📅 1991 🏛 American Chemical Society 🌐 English ⚖ 120 KB