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Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

✍ Scribed by Nuria Tamayo; Lillian Liao; Martin Goldberg; David Powers; Yan-Yan Tudor; Violeta Yu; Lu Min Wong; Bradley Henkle; Scot Middleton; Rashid Syed; Timothy Harvey; Graham Jang; Randall Hungate; Celia Dominguez


Book ID
108073579
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
217 KB
Volume
15
Category
Article
ISSN
0960-894X

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Substituted Isoxazoles as Potent Inhibit
✍ Stefanβ€…A. Laufer; Simona Margutti; Martinaβ€…D. Fritz πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 205 KB πŸ‘ 2 views

## Abstract __In a continuous effort to develop improved p38 MAP (mitogen‐activated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SB‐203580. 3,4‐ and 4,5‐disubstituted as well as 3,4,5‐trisubstit