Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase
β Scribed by Trejo, Alejandra; Arzeno, Humberto; Browner, Michelle; Chanda, Sushmita; Cheng, Soan; Comer, Daniel D.; Dalrymple, Stacie A.; Dunten, Pete; Lafargue, JoAnn; Lovejoy, Brett; Freire-Moar, Jose; Lim, Julie; Mcintosh, Joel; Miller, Jennifer; Papp, Eva; Reuter, Deborah; Roberts, Rick; Sanpablo, Florentino; Saunders, John; Song, Kyung; Villasenor, Armando; Warren, Stephen D.; Welch, Mary; Weller, Paul; Whiteley, Phyllis E.; Zeng, Lu; Goldstein, David M.
- Book ID
- 120014006
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 247 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2623
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## Abstract __In a continuous effort to develop improved p38 MAP (mitogenβactivated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SBβ203580. 3,4β and 4,5βdisubstituted as well as 3,4,5βtrisubstit