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DESIGN AND SYNTHESIS OF POTENT IN VIVO ANTAGONISTS OF OXYTOCIN

✍ Scribed by BANKOWSKI, KRZYSZTOF ;MANNING, MAURICE ;SETO, JENNY ;HALDAR, JAYA ;SAWYER, WILBUR H.


Book ID
115097668
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
688 KB
Volume
16
Category
Article
ISSN
0367-8377

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## Abstract Eleven new analogues were synthesized by modification of the potent oxytocin antagonist (OTA) [(S)Pmp^1^, D‐Trp^2^, Pen^6^, Arg^8^]‐Oxytocin, or PA (parent antagonist), in which (S)Pmp = Ξ²,β‐(3‐thiapentamethylene)‐β‐mercapto‐propionic acid. By internal acylation of Lys, Orn, L‐1,4‐diami