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Design, Synthesis, and Pharmacological Characterization of Novel, Potent NMDA Receptor Antagonists

✍ Scribed by Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Barberis Negra, Federico F.; Nielsen, Birgitte; Stensbøl, Tine B.; Madsen, Ulf; Bräuner-Osborne, Hans; Frydenvang, Karla; De Sarro, Giovambattista; Toma, Lucio; De Micheli, Carlo


Book ID
118194331
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
187 KB
Volume
47
Category
Article
ISSN
0022-2623

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Synthesis of a novel water-soluble NMDA
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## Abstract magnified image A novel water‐soluble __N__‐methyl‐D‐aspartate (NMDA) receptor antagonist ATGDMAP **1** as synthesized and the effect of **1** on NMDA receptors was studied using voltage‐clamp recordings of recombinant NMDA receptors expressed in __Xenopus__ oocytes. The compound **1**